Disorders in immune system and lymphocyte function lead to immune diseases or cancer. We aim at studying the molecular mechanisms underlying immune mediated diseases aiming at enabling individualized treatment in the future.
Projects
Molecular Systems Immunology group aims at understanding the regulation of human immune system to predict, prevent and treat immune mediated disorders. We study epigenetic and transcriptional regulation of T cells and molecular mechanisms of immune mediated diseases such as Type 1 Diabetes.
Project 1. is focused on studying how the novel long noncoding RNAs we have identified influence human T cell differentiation and their role in autoimmune diseases and cancer (Andrabi et al. Proc Natl Acad Sci U S A. 121:e2315363121, 2024 PMID: 38805281, Khan et al. Front. Immunol., 13: 856762, 2022 PMID: 35784351 and unpublished results).
Project 2. in collaboration with Orion Pharma Immuno-Oncology team studies molecular basis of human T cell exhaustion in cancer (Brunell et al. Front Immunol 14:1151632, 2023 PMID: 37122741 and unpublished results). A range of methods including single-cell genomics, mass cytometry, proteomics and CRISPR-Cas9 will be used in experimental work along with computational tools to address the questions.
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